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The Origin Recognition Complex requires chromatin tethering by a hypervariable intrinsically disordered region that is functionally conserved from sponge to man

Nucleic Acids Research, 2024 (in press)

Adiji OA, McConnell BS, Parker MW

Protein intrinsically disordered regions have a non-random, modular architecture

Bioinformatics, 2023

McConnell BS, Parker MW

Molecular determinants of phase separation for Drosophila DNA replication licensing factors

eLife, 2021

Parker MW, Kao JA, Huang AT, Berger JM, Botchan MR

A new class of disordered elements controls DNA replication through initiator self-assembly

eLife, 2019

Parker MW, Bell M, Mir M, Kao JA, Darzacq X, Botchan MR, Berger JM

Design, synthesis, and evaluation of a novel benzamidine-based inhibitor of VEGF-C binding to Neuropilin-2.

Bioorganic Chemistry, 2020

Said AM, Parker MW, Vander Kooi CW

Mechanisms and regulation of DNA replication initiation in eukaryotes.

Critical Reviews in Biochemistry and Molecular Biology, 2017

Parker MW, Botchan MR, Berger JM

Plate-Based Assay for Measuring Direct Semaphorin-Neuropilin Interactions.

Methods in Molecular Biology, 2017

Parker MW, Vander Kooi CW

Expanding the 3-O-Sulfate Proteome--Enhanced Binding of Neuropilin-1 to 3-O-Sulfated Heparan Sulfate Modulates Its Activity.

ACS Chemical Biology, 2016

Thacker BE, Seamen E, Lawrence R, Parker MW, Xu Y, Liu J, Vander Kooi CW, Esko JD.

Structural basis for VEGF-C binding to neuropilin-2 and sequestration by a soluble splice form.

Structure, 2015

Parker MW, Linkugel AD, Goel HL, Wu T, Mercurio AM, Vander Kooi CW

Structural mechanism of laforin function in glycogen dephosphorylation and lafora disease.

Molecular Cell, 2015

Raththagala M, Brewer MK, Parker MW, Sherwood AR, Wong BK, Hsu S, Bridges TM, Paasch BC, Hellman LM, Husodo S, Meekins DA, Taylor AO, Turner BD, Auger KD, Dukhande VV, Chakravarthy S, Sanz P, Woods VL Jr, Li S, Vander Kooi CW, Gentry MS.

Control of  cellular motility by neuropilin-mediated physical  interactions.

Biomolecular Concepts, 2014

Li X,  Parker MW, Vander Kooi CW

Microplane-based screening for small molecule inhibitors of neuropilin-2/vascular endothelial growth factor-C interactions.

Analytical Biochemistry, 2014

Parker MW, Vander Kooi CW

Mechanistic basis for the potent anti-angiogenic activity of semaphorin 3F.

Biochemistry, 2013

Guo HF, Li X, Parker MW, Waltenberger J, Becker PM, Vander Kooi CW

Effect of C-terminal sequence on competitive semaphorin binding to neuropilin-1

The Journal of Molecular Biology, 2013

Parker MW, Linkugel AD, Vander Kooi CW

Mechanism of selective VEGF-A binding by  neuropilin-1 reveals a  basis for specific ligand inhibition.

PLoS One, 2012

Parker MW, Xu P, Guo HF, Vander Kooi CW

Function of members of the neuropilin family as essential pleiotropic cell surface receptors.

Biochemistry, 2012

Parker MW, Guo HF, Li X, Linkugel AD, Vander Kooi CW

Structural basis for selective vascular endothelial growth factor-A (VEGF-A) binding to neuropilin-1.

The Journal of Biological Chemistry, 2012   

Parker MW, Xu P, Li X, Vander Kooi CW

Furin processing of semaphorin 3F determines its anti-angiogenic activity by regulating direct binding and competition for neuropilin.

Biochemistry, 2010

Parker MW, Hellman LM, Xu P, Fried MG, Vander Kooi CW

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